الفهرس 
Bronchial AsthmaOnly 14 pages are availabe for public view
 |  | from | 164 |  |  |
| | | from | 164 | | |
Abstract
Summary
Asthma is a common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction and bronchospasm.
Asthma is a highly prevalent disease affecting 300 million people world-wide.
Airway remodeling may be responsible for irreversible airway obstruction in asthma, Histological changes that define airway remodeling include smooth muscle hyperplasia and hypertrophy, vascular proliferation, increased number of bronchial glands, and collagen deposition.
A low post-bronchodilator FEV1/FVC ratio can be used as a noninvasive marker of airway remodeling.
Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa glycoprotein first identified as a matrix protein of specific granules of human neutrophils. NGAL is secreted by neutrophils and other cells .The role of extracellular matrix proteins in the process of airway remodeling is well known.
The aim of this study is to evaluate the role of serum neutrophil gelatinase - associated lipocalin as a marker of airway remodeling in childhood asthma in comparison with post bronchodilator FEV1/FVC ratio.