الفهرس 
TEMPORAL LOBE EPILEPSY; CLINICALOnly 14 pages are availabe for public view
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Abstract
Imaging of Temporal lobe epileptics (TLE) frequently
appears normal on conventional magnetic resonance imaging
(MRI) also patients suffer from multiple cognitive affection that
could be related to structural defects. Modern MR Techniques
are helpful in assessment of patient with seizures as Diffusion
Tensor Imaging (DTI). This study aims at evaluating the
presence of extratemporal involvement in TLE not visualized
by conventional MRI brain using DTI, and to correlate these
findings with associated cognitive dysfunction. Forty patients
with TLE and 10 healthy subjects had performed conventional
MRI epilepsy protocol, followed by DTI. MR tractography was
performed for 14 regions of interest (ROIs) and tracts.
Fractional anisotropy (FA) and apparent diffusion coefficient
(ADC) values were measured and then compared quantitatively
as an assessment of pertinent regions. Patients and controls
underwent Wisconsin card scoring test, Benetton visual
retention test and Wechsler Adult Intelligence Scale IV. All
data was correlated with the clinical and advanced EEG of the
patient. The patients group had significantly decreased FA
values and increased ADC values in multiple tracts and ROIs
ipsilateral and contralateral to the seizure focus, which was
positively correlated with the cognitive function deficit in those patients. We concluded that patients with TLE had significant
abnormalities in both hemispheres ipsilateral and contralateral
to seizure foci that could be a cause for the cognitive function
deficits in those patients.