الفهرس 
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Abstract
Acute leukemia is the most common malignancy in childhood. ALL is more common than AML. Teshnizi and his colleagues had shown in their study that more than 83% from leukemia patients have ALL and the most frequent ALL subtype is B cell precursor leukemia.
We still know little about the etiology of ALL and Less than 5% of ALL cases are connected to genetic syndromes.
Newest studies had shown that allelic variants in the microRNA coding genes have effects on the function of mRNA and contribute to cancer susceptibility.
There have been several genome wide association studies conducted to identify the possible genetic risk factors. In one of the studies two allelic variations rs10821936 and rs10994982 were identified as possible ALL risk alleles which are localized in ARID5B gene. The association between ARID5B gene variants and ALL risk has also been confirmed for different ethnic groups.
We aimed in our research to delineate the relationship between ARID5B rs10821936 gene polymorphism and childhood acute lymphoblastic leukemia in Egyptian children.