الفهرس 
HCV OverviewOnly 14 pages are availabe for public view
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Abstract
Hepatitis C is the most common liver disease in renal dialysis
patients while liver disease itself is a significant cause of morbidity and
mortality in patients with end-stage renal disease (ESRD) treated by
dialysis or transplantation.
••The relation between HCV infection and kidney disorders is
well recognized. On one hand, hepatitis C infection has been associated
with essential mixed cryoglobulinemia that may lead to
membranoproliferative glomerulonephritis , but on the other hand,
patients with renal disease are at an increased risk of acquiring HCV
because of prolonged vascular access and the potential for exposure to
infected patients and contaminated equipment.
••This work is a part of project aiming at making survey about
HCV, assessment its prevalence, its seroconversion and study risk
factors associated with HCV seroconversion among all hemodialysis
patients in Egypt. This project is modulated by Nephrology department,
Ain Shams university.
••Our study was conducted on all patients on regular
hemodialysis sessions attending different hemodialysis centers in EL
Menofia governorate sector (A) which includes Shebin EL Kome city,
Menof city, El Bagor city and Sers El Lian city.
••In this multicenter study, we sought to investigate the
prevalence of HCV infection among all hemodialysis patients in EL
Menofia governorate (sector A), to include an estimation of the anti-
HCV seroprevalence and to delineate events and factors associated
with HCV seroconversion.All patients in the work were evaluated using questionnaire
form for assessment of risk factors causing HCV infection in
hemodialysis patients such as; Age by years, Sex, Duration of
hemodialysis by months, Previous blood transfusion, Previous surgery,
Isolation procedures in the centers, Dialysis in other centers, Vascular
access used, History of Shistosomiasis, History of HBs Ag, Family
history of hepatitis, Cause of chronic kidney disease.
••The study was done in April&May 2010.
••The total number of patients was 640 ones attending about 11
different center.
••The total number of –ve HCV patients from the start of their
dialysis is 341 ones. 298 ones 0f them still free of HCV and 43 ones
converted to positive state through out their duration of HD.
••This study revealed that, the total number of the HCV positive
patients was 342 (53.27%), while the total number of the HCV negative
patients was 298 (46.73%).
••our study included 400 male patients (62.5%) and 240 female
patients (37.5%), the age of the patients ranged from 13 years to 86
years (mean 49.6 ± 16.2).
••The present study concluded that there is no significant
relationship between the conversion in the hemodialysis patients and
age or sex.
••Also the statistical analysis denoted that there is no significant
relationship between the rate of conversion of the HCV negative
hemodialysis patients and their duration of dialysis.
••In our study, the results showed significant correlation between
the conversion of the hemodialysis patients to the HCV positive state
and dialyzing in more than one center.••In our study, there is no significant relationship between the
conversion to the positive HCV state and the type of vascular access
while there is a significant relationship between the conversion to the
positive HCV state and the number of catheters.
••the statistical analysis denoted that there is no significant
relationship between the rate of conversion of the HCV negative
hemodialysis patients and previous blood transfusion.
••In the present study, there was no relationship between
conversion to HCV positive state and previous surgeries done.
••In our study, there is no significant relationship between the
conversion to the positive HCV state and infection with HBV or with
bilharziasis.
••In our study, there is no significant relationship between the
conversion to the positive HCV state and family history of hepatitis.
••Finaly, many results highlight the importance of isolation as a
policy to combat HCV infection among hemodialysis patients, this
doesn’t agree with the present study which concluded that there is no
significant relationship between the conversion in the hemodialysis
patients and isolation neither by place nor by machine.
Consequently, nosocomial practices seem to be the predominant
mechanism of HCV transmission in the HD setting and isolation of
HCV-infected patients is not recommended as an alternative to strict
infection-control procedures for preventing transmission of bloodborne
pathogens .