الفهرس 
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Abstract
Background: Fatigue is a common side effect of antiviral therapy that affects patients’ overall wellbeing. The aim of the study was to examine the impact of a structured nursing protocol on minimizing selected side effects of Sovaldi among hepatitis C virus (HCV) patients at Kafer El-Sheikh Liver Institute in Egypt. Design: A quasi-experimental research design was conducted on a convenience sample of 100 patients complaining of fatigue. Measurements: Data of this study were collected through structured interview utilizing designed questionnaires that were developed by the researcher after reviewing the literature and previous research and Fatigue severity scale tool was used to assess fatigue levels in pre and post program implementation. Results: Among all subjects (n=100), the results indicated that 62 percent of participants reported having severe base line fatigue scores. Immediately after the intervention, 49 percent reported severe fatigue levels,15 and 14 percent reported severe fatigue levels at one and two months after the intervention respectively. Repeated measures (ANOVA) revealed significant correlations between fatigue levels and times of intervention as (F= 114.437& p=≤.001) with means and standard deviations as (M=36.00 &+SD=7.767), (M=32.02 &+SD=7.623), (M=21.13&+SD=9.168) & (M=15.82 &+SD=10.642) respectively. Conclusion: Patients fatigue levels were high at the baseline. However, the nursing intervention was effective in reducing fatigue levels.