الفهرس 
Origin of different histopathological types of Epithelial ovarian cancerOnly 14 pages are availabe for public view
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Abstract
Summary
Surface epithelial ovarian cancers are regarded as the most
challenging -to -deal -with causes of death among gynecological
malignancies due to late stages at time of diagnosis and therapy
resistance. Based on these concepts, newer strategies that may be
effective in predicting survival and enhancing sensitivity to
chemotherapy are continuously assessed and subjected to
experimental trials.
Surface epithelial ovarian tumors exhibit various pathological
features and are classified according to the classification of World
Health Organization 2014 into three broad categories based on
tumor behavior; benign, borderline and malignant, with each
category encompasses various histopathological subtypes.
TRAP1 is a member of the Heat Shock Protein 90 (HSP90)
family, which is mainly located in the mitochondria. TRAP-1
mRNA of 2225 nucleotides is transcribed from a single locus on
chromosome 16p13 in humans. It plays different roles in
carcinogenesis by maintaining energy homeostasis in transformed
cells and preventing apoptosis which contribute to tumor cell
survival under conditions of stress normally encountered during
neoplastic growth.
The Tp53 tumor suppressor gene is located on the short arm of
chromosome 17. This gene mutationis the most common genetic
event in human malignancy, including ovarian carcinomas. The p53
protein is suspected to various types of aberration such as deletion