الفهرس 
Chronic Kidney DiseaseOnly 14 pages are availabe for public view
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Abstract
Magnesium (Mg) is the fourth most abundant cation in the body and the second most important intracellular cation. In recent years, Mg has gained much importance with the growing awareness that Mg is required as a cofactor in multiple enzymatic reactions and that it plays an important role in neuromuscular process. Mg also has a role in mineral bone metabolism, adenosine triphosphate metabolism, neurotransmitter release and in the regulation of vascular tone, heart rhythm and platelet-activated thrombosis. In chronic kidney disease (CKD), Patients particularly those with end-stage renal disease (ESRD), are at much higher risk of Cardiovascular disease (CVD) than the general population. CVD is by far the leading cause of morbidity and mortality in dialysis patients, accounting for almost 40% of hospitalizations and almost 50% of deaths. The mechanisms underlying the accelerated vascular and cardiac calcification found in CKD and ESRD are partially understood. It seems that magnesium depletion may be the missing link between cardiovascular risk factors and atherosclerosis. Objective: To evaluate the relationship between serum Mg and atherosclerotic changes in patients with CKD on hemodialysis (HD). Methods: This cross-sectional study was carried on patients at Hemodialysis units, Internal Medicine Department at Tanta University Hospital over a period of one year (between April 2018 to April 2019). The study was performed on 60 patients on regular hemodialysis. All patients were subjected to history taking, examination, investigations (full routine laboratory investigations, super facial ultrasonography for measurement of intima media thickness (IMT) of carotid, femoral and brachial, color Doppler Abstract II ultrasound for measurement of peak systolic velocity (PSV) of the previous arteries and Doppler instrument for ankle brachial index (ABI). Results: A significant negative correlation was observed between serum Mg and carotid intima media thickness (CIMT). Conclusion: Low serum Mg is associated with increased CIMT so it may be considered as a risk factor of atherosclerosis in hemodialysis patients.