الفهرس 
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Abstract
In this vitro study, cinnamon, marjoram, black seed, garlic and onion extracts were investigated to evaluate the effect of plant extracts against MRSA, Ps. aeruginosa and C. albicans. Our results depieted that cinnamon, marjoram and black seed extracts have antibacterial effect against Methicillin resistant staphylococcus aureus (MRSA) and Ps. aeruginosa at 25% concentration while garlic and onion extracts have not antibacterial effect against MRSA and Ps. aeruginosa. Cinnamon extract only has the best antifungal activity to C. albicans (30 mm) at 25% concentration while marjoram, black seed, onion and garlic extracts have no antifungal activity to C. albicans. MIC of marjoram, cinnamon and black seed extracts against MRSA were 0.78 mg/ml , 1.56 mg/ml and 1.56 mg/ml respectively while MIC of cinnamon and marjoram extracts against Ps. aeruginosa were 0.39 mg/ml and 0.78 mg/ml, respectively and MIC of cinnamon extract against C. albicans was the most effective (0.39 mg/ml). Extracts from garlic, black seed, onion, marjoram and cinnamon had effect on myeloma cells morphology and viability at different time points (24h – 72h). Interestingly, myeloma cells morphology changed with visible damage to cells, marked decrease in growth rate and condensation indicative to apoptosis post exposure to garlic, black seed, onion, marjoram and cinnamon extracts compared to the control and it was time-dependent. The viability percentage of plant extract treated myeloma cells was decreased. Efficacy of cell death varied, depending on the type of plant extract. MTT of garlic, onion, cinnamon, black seed and marjoram treated myeloma cells showed a time dependent effect on the viability of myeloma cells with increase in intracellular caspase 3 activity following treatment with the plant extracts. Cinnamon showed the highest values followed by black seed, onion then garlic and marjoram. Decrease production of TNF-α cytokine in myeloma cells post exposure to cinnamon, black seed and onion extracts for 24 hr. The Bax gene expression was decreased in cinnamon, black seed and onion treated cells after 24.