الفهرس 
Introduction
Ulcerative colitisOnly 14 pages are availabe for public view
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Abstract
This study was planned to evaluate the possible protective and therapeutic effects of aqueous extract of rosemary (10 mg/kg B.W) and Plantago ovata husk (5 mg/kg B.W) compared with the synthetic antispasmodic drugs Colona ® on the extent and severity of ulcerative colitis (UC) caused by intracolonic administration of acetic acid in rats. Eighty rats were split to eight equal groups. First group (negative control) administrated saline, second group (positive control) treated with 4% acetic acid (1 ml once on 14th day I/R), third group pretreated with Colona® (0.5 mg/kg B.W / day orally for 14th day) before induction of colitis on 14th day, fourth group pretreated orally with aqueous extract of rosemary(10 mg/kg B.W / day orally for 14th day) before induction of colitis on 14th day, fifth group pretreated orally with Plantago ovata husk (5 mg/kg B.W / day orally for 14th day) daily for 14th day before induction of colitis on 14th day, sixth group was treated with 1 ml of 4% acetic acid once on 14th day and then 0.5 mg/kg B.W of Colona® orally daily for one week, the seventh group was treated with 1 ml of 4% acetic acid once on 14th day and then 10 mg/kg B.W of aqueous extract of rosemary orally/ day for one week, and the eighth group treated with 1 ml of 4% acetic acid once on 14th day and then 5 mg/kg B.W of Plantago ovata husk orally/ day for one week. Two Blood samples were collected from heart puncture of each experimental rat at 3rd week of experiment (the first one for hematological studies and collected in wesserman tube contains anticoagulant and the second sample for serological studies and collected in wesserman tube without anticoagulant) to evaluate hematological, biochemical parameters and immunostimulant parameters also colon tissue for histopathology. The obtained results revealed that, rosemary and husk induced a significant increase in red blood cells counts (RBCs), hemoglobin concentration (Hb) and packed cell volume (PCV%) and lymphocyte counts and a significant decrease in white blood cells (WBCs), neutrophils, monocyte and blood platelets in treated rats compared with the positive control group. In addition, both the tested plants evoked a significant increase in reduced glutathione (GSH), catalase (CAT) and interleukin-10 (IL-10) and a significant decrease in nitric oxide (NO) and interleukin-1β (IL-1β) in serum of treated rats in comparisons with the positive control group. The conclusion both rosemary (aqueous extract) and Plantago ovata husk have a positive effect on ulcerative colitis treated rats through improving hematological , antioxidant and the measured immunological parameters