الفهرس 
PART I: General Introduction & Review of literatureOnly 14 pages are availabe for public view
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Abstract
Oral anti-diabetic agents form an important therapeutic strategy in the management of diabetes, after lifestyle modification. The thesis is devoted to the development of new different analytical methods for the determination of antidiabetic drugs, namely: vildagliptin (VLD), saxagliptin (SAX) and sitagliptin phosphate (STP) in pharmaceutical preparations and/or biological fluids. This thesis comprises four main parts. The first one included a general introduction about oral antidiabetic drugs and their importance. A spectrofluorimetric method was proposed for the determination of SAX and STP in raw material, tablet preparations and in spiked human plasma depending on the reaction of both drugs with acetyl acetone-formaldehyde reagent (AAF) followed by investigation of the fluorescence spectral behavior of the formed fluorescent products in presence of Sodium Dodecyl Sulfate (SDS) micellar system as enhancer. Moreover, spectrophotometric and spectrofluorimetric methods were developed for the analysis of VLD, SAX and STP in pure form and tablets using eosin Y as an ion pair reagent in acidic media in pure form and tablets. Finally, different chemometric calibration models such as; (partial least squares and Artificial Neural Networks) were developed for determination of a ternary mixture of VLD, SAX and STP. The effect of genetic algorithm as a variable selection method on these different models was applied for the quantitative analysis of these drugs in the laboratory-prepared mixtures and their dosage forms based on the Ultraviolet spectral data. All the results were statistically analyzed and compared with those obtained by comparison methods.