الفهرس 
I DIOPATHIC THROMBOCYTOPENIC PURPURAOnly 14 pages are availabe for public view
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Abstract
Background: Immune thrombocytopenia (ITP) is a common autoimmune disorder characterized by immune-mediated accelerated platelet destruction and resulting in isolated thrombocytopenia.
Aim of the Work: This study aims at evaluation of prognostic value of interleukin 27 (IL-27) serum level in pediatric patients with acute, persistent and chronic ITP and its relationship with treatment response.
Patients and Methods: The study was conducted on 43 patients with ITP from Pediatric Hematology Clinic, Pediatric Hospital, Ain Shams University and 20 age and sex matched normal children as the control group. All the studied children were subjected to through history, clinical examination and laboratory investigations, including complete blood count (CBC) and IL-27 serum level using ELISA technique.
Results: The study revealed a significant decrease IL-27 level in ITP patients compared to control group with no significant difference between different categories of ITP as regards IL-27 serum levels. There was no significant relation between category of disease and platelet count, hemoglobin level and IL-27 during blood sampling (p=0.261, 0.426, 0.558 respectively). More than 50% of studies ITP patients received steroids; 76.7% of them did not respond to steroid therapy. There was a positive correlation between IL-27 level and duration of steroid intake in ITP patients (r=0.406, p=0.04).
Conclusion: The decrease in serum IL27 level in different categories of pediatric ITP patients might suggest its involvement in the pathophysiological process of ITP. IL-27 level might play a role in patients response to corticosteroid therapy