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العنوان
synthesis of some new peptides
/ attached to benzotriazole derivatives
المؤلف
el-asregi,samah kamel mahmoud abdel-latif
هيئة الاعداد
باحث / سماح كامل محمود عبد اللطيف
مشرف / احمد السيد عبد المجيد
مشرف / عادل عبد الهادي نصار
الموضوع
Chemistry
تاريخ النشر
2019
عدد الصفحات
155 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
17/4/2019
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء .
الفهرس
Only 14 pages are availabe for public view

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Abstract

3-(1H-benzo[d][1,2,3]triazol-1-yl)propanenitrile (2) was prepared in 62%
yield by treating benzotriazole (1) with acrylonitrile in DMF and in the presence of potassium carbonate. Tetrazole 3 was prepared in 63% yield by treating of the nitrile derivative 2 with sodium azide. Ester 4 was prepared in 69% yield by treating of the tetrazole derivative 3 with ethyl chloroacetate in dry acetone and potassium carbonate. The acetohydrazide in 66%yield 5 was synthesized by hydrazinolysis of the corresponding ester 4 in ethanol at reflux temperature