الفهرس 
Post-operative painOnly 14 pages are availabe for public view
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Abstract
Summary
Regional anesthesia can decrease episodes of nausea, vomiting
and postoperative pain by pre-emptive analgesic effect. Various
methods of regional anesthesia for breast surgery are in practice.
Simple infiltration methods provide adequate anesthesia for minor
procedures but patient discomfort, frequent supplementation and
distortion of anatomy may preclude their use for major procedures.
Thoracic epidurals are associated with cardio-respiratory and
physiological changes, which required an increased level of
monitoring when used for postoperative analgesia. Paravertebral
analgesia consistently achieves superior analgesia and inhibits the
surgical stress response at greater extent than epidural anesthesia.
It was found that the addition of a small dose of naloxone to
bupivacaine in intrapleural regional analgesia leads to prolonged pain
relief after thoracotomy, with a delayed request for rescue analgesia,
without any significant adverse effects.
We conducted this prospective randomized double- blinded
study on 90 adult patients ( ASA physical status I) scheduled for
elective modified radical mastectomy to evaluate the effect of
addition of ultra-low-dose of naloxone to thoracic paravertebral
bupivacaine mixture on the quality and the duration of postmastectomy
analgesia.
Patients were divided into group I (bupivacaine group) and
group II (naloxone group). The following data were recorded;
demographic data, vital signs (heart rate& MAP), depth of anesthesia