الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Systemic lupus erythematosus is a chronic autoimmune disorder of the connective tissue. The pathogenesis of SLE still unclear, environmental, genetic and hormonal factors play serious roles in SLE development.
IL-33 has been discovered as a new member of the IL-1 subfamily. Il-33 has a regulatory role in the activation, maturation and differentiation of a variety of immune cells. It is constitutively expressed by tissue cells such as epithelial and endothelial cells of many organs and by some innate immune cells such as macrophages and dendritic cells. IL-33 receptor (ST2) is selectively expressed on endothelial cells, epithelial cells and fibroblasts in many tissues which suggests the involvement of the IL-33-ST2 signaling pathway in many chronic inflammatory and autoimmune diseases.