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العنوان
The Use of Copper Monovalent Nicotinic Acid Complex for
Reducing Toxic Effect Caused by Acrylamide on Male Rat Liver /
المؤلف
Abd ElLah, Sabra Abd Ell El Aal.
هيئة الاعداد
مشرف / نجوي محمد الصاوي
مشرف / منير عباس علي
مشرف / احمد محمد رشاد
مشرف / هشام اسماعيل محمد عثمان
himosman@mu.edu.eg
مشرف / صابرة عبد العال عبد اللاه
الموضوع
biochemistry.
تاريخ النشر
2019.
عدد الصفحات
p 166. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
28/9/2019
مكان الإجازة
جامعة سوهاج - كلية العلوم - كيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Acrylamide (AA) is a low molecular weight, water soluble vinyl
monomer it is odorless, colorless, rapidly polymerizable and
crystalline substance. Acrylamide is found in carbohydrates-rich
food prepared at high temperatures such as potato chips and French
fries which are consumed by human. Its metabolite a glycidamide;
an epoxide derivative; is more reactive toward proteins and DNA
than acrylamide, the parent compound. Cytochrome P450 is known
to be involved in AA metabolism in the liver changing it to
glycidamide ,the active genotoxic product of AA .Fourty white
male rats were randomly divided into 4 groups (10/group). GI:
control group kept on balanced diet and tap water, GII:
Acrylamide group received acrylamide orally in drinking water
(7.5 mg/kg b.w.) for 30 days .GIII: treated with Copper (I)-
nicotinate complex (400 μg/kg b.w.) after acrylamide intoxication
for 30 days and GIV: Copper (I)-nicotinate complex then .