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العنوان
Neurobehavioral Toxicity of Propiconazole Fungicide and a Trial for Protection in Rats /
المؤلف
Noshy, Peter Azmy.
هيئة الاعداد
مشرف / بيتر عزمي نصحي
مشرف / محمد علي محمد الهادي
مشرف / عبد العظيم علي أحمد خلف
مشرف / ميرفت محمود كامل
الموضوع
Oregano. Brain. Oxidative stress.
تاريخ النشر
2019.
عدد الصفحات
154 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
البيطري
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة القاهرة - كلية الطب البيطري - Toxicology and Forensic Medicine
الفهرس
Only 14 pages are availabe for public view

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Abstract

Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of AChE enzyme in neural tissue was also observed in PCZ-exposed rats. The comet assay revealed a high percent of DNA damage in the brain of rats exposed to PCZ. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, concurrent administration of CAR ameliorated most of the undesirable effects of PCZ.