الفهرس 
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Abstract
N-Aryl chloroacetamide derivatives were utilized as versatile precursors for the synthesis of various types of sulfides and phenoxy-acetamides, and two sulfur-containing heterocyclic systems (namely; thiophene and thiazole). The chemical reactivity of the bifunctional N-(4-acetylphenyl)-2-chloroacetamide towards various types of nucleophiles such as phenylhydrazine at the ketonic carbonyl group of acetamide and condensation of chloroacetamide derivatives with 2-cyanoacetohydrazide and thiosemicarbazide and aromatic aldehyde derivatives to synthesis Chalcone compounds and reactivity the chloroacetamide derivatives with diazonium salt for aromatic amines. The biological activity of the synthesized N-aryl chloroacetamide based towards anti-bacterial properties were explored against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). and newly constructed heterocycles derived from chloroacetamide derivatives were estimated for their antioxidant activities by using the ABTS Radical Cation Decolorization Assay.