الفهرس 
SILDENAFIL CITRATEOnly 14 pages are availabe for public view
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Abstract
Back ground Researchers’ defined recurrent miscarriage as three or more pregnancy losses, the available research data denotes that the risk of abortion is 30% and 33% after two miscarriages and three miscarriages, consecutively. Sildenafil citrate (a type 5-specific phosphodiesterase inhibitor, augments the vasodilatory effects of NO. Vagina sildenafil augments the vasodilatory effects of NO. NK cytotoxicity has been reported to be predictive of subsequent pregnancy loss in women who had recurrent spontaneous abortions (RSA).
Aim Is to investigate whether sildenafil citrate affect peripheral natural killer cells successful in women with history of recurrent pregnancy loss.
Methodology An interventional research study, with one arm clinical trial: one group of study subjects were administered the sildenafil citrate without comparative placebo effect, conducted at the Obstetrics and Gynecology Outpatient clinic at Ain Shams University hospital throughout 2017-2018. The sample size consists of 77 women within the reproductive age (from 18 to 35 years old) having a history of recurrent pregnancy loss
Results there was a statistical significant reduction in peripheral blood natural killer cell activity after having vaginal sildenafil .(p value <0.001), there was no statistical significant correlation between peripheral blood natural killer cell activity (%) and other demographic characteristics(age, BMI, parity, miscarriages, time from last miscarriage, p values before =0.204, 0.929, 0.416, 0.302,0.627, consecutively, p values after intervention =0.133,0.709,0.380,0.410,0.559,consecutively,p values of reduction =0.794, 0.458, 0.687, 0.181, 0.944,consecutively)
Conclusions
The current research reveals and displays that vaginal sildenafil citrate is a potentially promising agent in managing cases with recurrent miscarriage and it reduces the natural killer cell activity levels.