الفهرس 
ATOPIC DERMATITISOnly 14 pages are availabe for public view
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Abstract
A
Ctivin- A is a member of the TGF-β superfamily, and previously observed that activin A is important in driving allergic pathology.
The aim of this study is to assess the role of activin-A in patient with atopic dermatitis (AD) through measuring its level in activity and in remission.
A cross sectional study on 24 children suffering of AD from Pediatric Allergy and Clinical Immunology unit, Ain Shams University. Thirty age and sex matched children with no history of allergic disease was recruited from out-patient clinic of Ain Shams University as a control group.
All patients included in this study were subjected to:
• Full history taking
• Assessment of AD disease activity based on SCORAD
• Laboratory investigations including:
1. Complete Blood Count (CBC):
2. IgE assessment by ELISA.
3. Serum level of Activin A by ELISA.
Results of the current study showed that there is not significant value (P value = 0.051) positive family history of allergy in patients with atopic dermatitis, as regards the type of allergy in the family, there is significant higher (P value = 0.049) in positive history of allergic rhinitis in family of patient with atopic dermatitis.
There are significant higher levels of blood esinophils and monocytes in patients with atopic dermatitis.
Serum IgE levels were significantly higher (p value <0.001) in AD patients to (58.2±21.7) than in controls (8.3±2.7)
In addition, serum activin-A levels were significantly higher (P value ≤0.001) in patients with AD, with mean ±SD (647.2±269), than in controls were (62.3±35.3).
Results of SPT of cases showed that 3 were atopic to HDM, 7 were to strawberry,3 were atopic to asperigellus, 10 were atopic to cow milk, 3 were atopic to chocolate, 2 were atopic to tomato,8 were atopic to egg, 7 were atopic to pollens. As regard to controls were negative skin prick test.
Serum activin-A levels were significantly increased (P value ≤0.001) in patients with atopic dermatitis during activity than in remission.
There is negative correlation between size of wheal of skin prick test and SCORAD score.
In addition there is positive correlation between age of onset of AD in patients and SCORAD score.
In conclusion, activin-A is important in driving allergic pathology. It may play a role in development of AD and in the activity of the disease.
We recommend assessment of activin-A as a marker for atopic dermatitis as it may help in identifying the disease. Further studies are needed to investigate the possible role of anti-Activin-A in treatment of AD.