الفهرس 
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Abstract
Cow’s milk protein allergy (CMPA) is the most common food allergy in children, which affects approximately 2 % of children under the age of four.
Mechanisms underline CMPA are various, either IgE-mediated (The immediate hypersensitivity type I) mechanism, non-IgE-mediated mechanisms (type II, type III or type IV hypersensitivity) -which occur in most of the cases - or mixed mechanisms.
The first step in CMPA diagnosis is a good medical history followed by physical examination. The diagnosis needs to be confirmed or excluded by an allergen elimination and challenge procedure. This can be performed as open, single-, or double-blind challenge, depending on symptoms, history, and age of the child. The determination of specific IgE in a blood sample or the skin prick test (SPT) are useful diagnostic tests at any age in IgE mediated CMPA.
The aim of this work was to study two single nucleotide polymorphisms i.e. near toll like receptor-6 (TLR6) gene rs17616434 (C/T) and interleukin-2 (IL2) locus rs2069772 (C/T) in Egyptian children affected with cow’s milk protein allergy (CMPA) .
To achieve this goal the study was conducted on 50 patients diagnosed as CMPA patients and 40 healthy subjects with matched age and sex.
All subjects included in the study were subjected to the following:
Full history taking, complete blood picture, determination of specific IgE in a blood sample and elimination trial followed by rechallenge test. Detection SNP rs17616434 (C/T) and SNP rs2069772 (C/T) were performed by TaqMan real-time polymerase chain reaction.
The results