الفهرس 
GENERAL INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The oral route of drug delivery, being the least expensive and safer than other routes, is considered the most convenient route of drug administration. Oral dosage forms include conventional and sustained release products. Oral sustained release formulations offer many advantages over conventional dosage forms. Unfortunately the majority of these sustained release formulations are in the form of solid dosage forms which are not suitable for children and other patients with difficulty in swallowing. This reflected the need for developing liquid oral sustained release dosage form. In situ gelling techniques provide smart promising means to develop controlled drug release formulations. In situ gelling systems depend on utilizing polymers which undergo gelation upon exposure to a physiological trigger like temperature change and/or pH change. However, these systems undergo immediate phase transition from gel to sol on increasing the pH as a result of gastric emptying. Accordingly, if premature gastric emptying takes place, dose dumping will occur. Losartan potassium is a water soluble antihypertensive agent with short half-life. Controlling its release will improve patient compliance. The benefit will be extended for geriatric patients if the developed system was liquid. The objective of this work was to develop controlled release oral liquid losartan potassium. This employed a combination of in situ gelation.