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Abstract Despite extensive research, the cardiovascular effects of coffee consumption in humans remain controversial; our aim was to investigate the risk of heart disease that elevates the levels of homocysteine in blood plasma due to consumption caffeinated and decaffeinated coffee. The importance of the study is to find a healthy and caffeine-free beverage that similar to coffee, to use date pits (seeds) as an alternative to coffee contain a high amount of phenols that have an antioxidant activity to protect against the risk of heart disease as well as to use the date pits as a functional food component which a good source of dietary fiber, and phenolic compounds. Also, contain a considerable amount of protein, fats, and minerals. This study was undertaken to investigate the effect of different concentrations low and high (5 and 10 g/100ml), from caffeinated, decaffeinated and date pits powder coffee on total homocysteine and blood profiles in albino male rats. Forty-two adult male albino rats, weighting (100-150g) were divided randomly into seven groups, each group had six rats. The first group: Control group was fed on a standard basal diet and water. The second group: Rats were fed on a standard diet and caffeinated (low concentration 5%). The third group: Rats were fed on a standard diet and caffeinated (high concentration 10%). The fourth group: Rats were fed on a standard diet and decaffeinated coffee (5%). The fifth group: Rats were fed on a standard diet and decaffeinated coffee (10%). The sixth group: Rats were fed on a standard diet and date pits coffee (5%). The seventh group: Rats were fed on a standard diet and date pits coffee (10%). |