الفهرس | Only 14 pages are availabe for public view |
Abstract Alzheimer’s disease (AD) as a chronic neurodegenerative disease, is characterized by early loss of specific cholinergic neurons in the basal forebrain (BFCBs). Looking for a suitable source for regeneration of these damaged BFCNs is the current scope for several researchers to restrict the progression of AD. Although, the diffusible ligands, SHH, FGF8, BMP9, and NGF have been successfully used to differentiate cholinergic neurons from human embryonic stem cells in vitro, but the potential of these factors to induce OBNSCs differentiation into cholinergic neurons has not been evaluated yet. Therefore, this study aim to generate cholinergic neurons with basal forebrain fat (BFCNs) from hOBNSCs using diffusible ligands and to study the gene expression profile for the key genes involved in this differentiation. |