الفهرس 
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Abstract
Aim:
This cross sectional study was designed to provide information on the frequency of hypodontia in children cancer survivors who received chemotherapy before 4 years of age.
Methods:
The study sample included 144 cancer survivors who received anti neoplastic chemotherapy at the Children Cancer Hospital Egypt 57357. Subjects
were selected using stratified random sampling and those who met the eligibility criteria were asked to attend to fill a questionnaire followed by taking a panoramic radiograph.
Dental Panoramic radiographs were examined to assess dental abnormalities,
excluding third molars, which were then evaluated using Holtta’s Defect Index
(DeI).
Results:
The Mean age of the study sample was 10.22 (± 2.81) years old at examination
and 2.56 (± 1.02) years at start of chemotherapy. The mean DeI for the study
population was 9.3± 10.13.
70.14% of the study population had at least one dental anomaly. The total
frequency of hypodontia in the study population was 9.72%.
In the current study, hypodontia occurred mostly in second premolars
(54.17%) followed by second permanent molars (20.83%), first premolars
(16.66%) and lateral incisors (8.34%). Also, it occurred most commonly with bone tumors 1 out of 3 (33.33 %), followed by Langerhan’s Cell Histiocytosis 2 out of 7 (28.57 %) where as the least counts revealed were with Acute Lymphoblastic Leukemia 2 out of 55 (3.64 %) and no results were found with Acute Myeloid Leukemia, Brain tumors, Germ Cell Tumor, Hodgkin’s Lymphoma, and Soft tissue sarcomas.
The mean of Holtta’s defect index DeI of the study population was 9.3 ±10.13. Bone tumors was revealed as the tumor type with the highest DeI mean score 19.67±18.61 followed by Acute Lymphoblastic Leukemia 12 ±11.32.Soft
tissue sarcoma showed the least DeI mean score with 2±4.
However, there was no statistical significant difference between tumor types for D5 (hypodontia), D4 (microdontia), D2 (R/C ratio 0.9-1.1; severe disturbance) and DeI. Still, there was a significant statistical difference between tumor types for
D1(R/C ratio 1.2-1.6; mild disturbance) and D3 (R/C ratio <0.9; arrested root
development). There was also significant statistical difference between the defect indices for Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Germ Cell Tumor, Neuroblastoma, Non-Hodgkin’s Lymphoma and Renal tumors.