الفهرس 
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Abstract
Cancer continuous to represent the largest cause of mortality in the world and claims over 6 million lives every year (Abdullaev et al., 2000). An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in humans. Hepatocellular carcinoma (HCCs) develops in the context of chronic liver diseases, hronic liver injury generally induces liver fibrosis, followed by cirrhosis, (Simonetti et al., 1991). CCl4 has been widely used experimentally to induce liver injury in rodents. A single dose of CCl4 leads to centrizonal necrosis and steatosis, ( Pierce et al. 1987), while prolonged administration leads to liver fibrosis, cirrhosis, and HCC, ( Perez , 1983). CCl4 impairs hepatocytes directly by altering the permeability of the plasma, lysosomal, itochondrial membranes. Highly reactive free radical metabolites are also formed by the mixed unction oxidase from the foregoing it is concluded that, the use of colostrum or coenzyme Q10 reducing the severity of the hepatorenal toxicity induced experimentally by EAC cells and CCl4 in female mice as well as to reduce the turbulence observed in the rest of the criteria associated with the occurrence of the toxicity, vital activity of experimental animals exposed to cancer encouraging further work to extend through this point of view. It seems that colostrum is more effective in blocking the adverse effect caused by EAC cells and CCl4 than coenzyme Q10 due to the nature of immune cells and many antibodies found in it.