الفهرس 
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Abstract
Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterized by intense itching and recurrent eczematous lesions. Although it most often starts in infancy and affects two of ten children, It is also highly prevalent in adults.The risk of developing atopic dermatitis is much higher in those whose family members are affected.
Many genes have been associated with atopic dermatitis, particularly genes encoding epidermal structural proteins and genes encoding key elements of the immune system.
Although many different environmental risk factors have been considered potentially causative for atopic dermatitis.
The theory of immunological imbalance argues that atopic dermatitis results from an imbalance of T cells, particularly T helper cell types 1, 2, 17, and 22 and also regulatory Tcells (14). In the allergic (atopic dermatitis) state particularly in acute eczema the Th2 differentiation of naive CD4+ T cells predominates.
This causes an increased production of interleukins, primarily IL4, IL-5, and IL-13, which then leads to an increased level of IgE, and the Th1 differentiation is correspondingly inhibited.
Recently, several studies have shown that different serum parameters were reported to reflect the inflammation in AD including the total serum IgE levels and sE-selectin levels which were increased in atopic dermatitis patients and correlated positively with disease severity.