الفهرس 
Chapter (I) Introduction and aim of the work, Review of literatureOnly 14 pages are availabe for public view
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Abstract
Introduction: Liver is a unique organ in the human body. Many vital functions are attributed to it. Hepatitis C is one of the most diseases which intimidate liver integrity. Patients with chronic hepatitis C (CHCV) have increased levels of intrahepatic chemokine. Aim of the work: We aimed to clarify the association between single nucleotide polymorphism of CCL3, CCL2, CCR2 and CCR5 and the outcome of HCV infection. Subjects and method: a total of 402 Subjects were recruited and classified into three main groups categorized as (I) spontaneous viral clearance (SVC) (N=57), (II) chronic HCV patients (CHCV) (N=205) and (III) control negative (N=140) where they were genotyped for SNP CCL3 (hcv1568115) and (hcv11420414), CCL2 gene we studied two SNPs (rs1024611 and rs2857656), CCR2 gene at (rs1799865) and a thirty two base pair deletion in CCR5 gene at rs333 using allelic discrimination real-time PCR. Results: The carriage of the G allele of CCL3 hcv1568115 was significantly higher in CHCV group compared to that of SVC (odds ratio [OR] 2.17) and to that of controls (2.39) (both P < 0.01) but weren’t significantly higher in SVC group when compared to that of controls (0.9) (P > 0.01). The carriage of the G allele of CCL3 hcv1568115 was significantly higher in CHCV group compared to that of SVC (odds ratio [OR] 6.8) (P < 0.01) but this carriage allele isn’t significant comparing to that of control (1.67) and SVC groups when compared to that of controls (4.06) (both P > 0.01). Conclusion: persistence of HCV infection is associated with G alleles of hcv1568115. G allele of CCL2 (rs1024611) is strongly associated with the susceptibility to the HCV infection. G allele of CCL2 (rs2857656) may act as protective allele against HCV infection. C allele of CCR2 (rs1799865) is strongly associated with the susceptibility to the HCV infection.