الفهرس 
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Abstract
The object of the current thesis was for formulation of nanosponges prepared by cross linking β-cyclodextrin and diphenyl carbonate in three different ratios, with the rationale to design a vaginal gel formulation for the antifungal drug (Miconazole nitrate) with improved availability, mucoadhesive properties to ensure longer residence at the infection site and favorable release profile.
The study revealed the following:
The FTIR studies proved that there was no interaction between the drug and cyclodextrin.
The gel formulations were prepared using different Polymers (Carbopol, hydroxypropyl methyl cellulose, sodium carboxy methyl cellulose and methyl cellulose) .
The pH values of all formulations were around the skin pH range (4.74 to 5.01) reflecting no risk of skin irritation on application.
The formulations were characterized for drug content. The Drug content of the formulations was observed to be between 97.8 – 101.8 .%
All gels were found to exhibit plastic flow with shear thinning indicating structural breakdown of the existing intermolecular interactions between polymeric chains.
The in-vitro release of Miconazole Nanosponge Gel formulation showed that gels prepared with the Methyl cellulose, Sodium carboxy methyl cellulose, Carbopol 934 and Hydroxy propyl methyl cellulose shown drug diffusion for a period of 8.5 hours, 9 hours, 10.5 hours and 12 hours respectively .
cyclodextrin hydrogel network was able to sustain the delivery of MN during at least 14 days.
Anti-fungal activity of Miconazole Nanosponge Gel showed highest zone of inhibition in comparison to Marketed Sample.
It was concluded that the Miconazole loaded Nanosponge Gel may have increased the solubility, drug release and Antifungal activity (Increase in Zone of Inhibition), and provide Sustained effect