الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 181 |  |  |
| | | from | 181 | | |
Abstract
The effectiveness of genotype VII NDV inactivated virus vaccine was
compared to Lasota inactivated vaccine using two different adjuvants,
Montanide ISA71 and anew promising CNPs as anano adjuvent in chickens.
Results of this study showed that protection levels of GVII inactivated vaccines
was higher than Lasota one. GVII NDV vaccines gave 100% protection level
against challenge by virulent NDV genotype VII , followed by Lasota group
adjuvanted with Montanide which gave 93.66% protection followed by 87.33%
protection for Lasota group adjuvanted with CNPs respectively. Shedding of
NDV in cloacal and tracheal swabs in genotype VII vaccinated groups were
lower than Lasota one , results of HI test of virulent NDV genotype VII
vaccinated groups before challenge was higher than Lasota adjuvanted group ,
also CNPs adjuvanted group elicited earlier and higher immune response one
week post vaccination. In all tested groups CNPs adjuvanted group evoked
better stimulation and phagocytic indices with upregulation of IL6 , IL18 , γ
IFN than Montanide adjuvanted groups. In conclusion homologus inactivated
vaccines to current circulating velogenic NDV will provide better protection
levels than that obtained by inactivated Lasota strains and shed lower amount of
virus than lasota inactivated vaccines so it will decrease spread of NDV among
poultry flocks. CNP can offer apotent and promising adjuvent efficiency for
inactivated ND vaccines specially with genotype VII inactivated vaccine.