الفهرس 
PathophysiologyOnly 14 pages are availabe for public view
 |  | from | 101 |  |  |
| | | from | 101 | | |
Abstract
PAD is highly associated with cardiovascular mortality and morbidity,
and smoking cessation, lifestyle modification, and medical treatment, along
with concomitant evaluation for cardiovascular risk, is a well-established
treatment regimen.
Endovascular revascularization or surgical reconstruction often
becomes necessary to restore blood flow to the diseased limb.
Antiproliferative agents, such as paclitaxel, delivered into the vessel
wall by drug-coated balloons (DCB) or drug-eluting stents have been shown
to inhibit restenosis and improve patency in the infra inguinal arteries
compared with uncoated balloon angioplasty alone. DCB and drug eluting
stent strategies are both currently being investigated to optimize
interventional treatment of infrainguinal atherosclerotic vascular obstructions.
However it remains a matter of some debate whether the use of DCB
for femoropopliteal percutaneous revascularization may lower the risk of reinterventions. Indeed, any such benefit may have considerable implication for the costs associated with peripheral artery disease and its complications.