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العنوان
Study of Non-alcoholic fatty liver disease among chronic kidney disease patients by Controlled attenuation parameter \
المؤلف
Salem, Mohamed Mahrous.
هيئة الاعداد
باحث / محمد محروس سالم
مشرف / سحر محمود شوقي
مشرف / مها عبد المنعم بحيري
مشرف / أحمد فؤاد حلمي
تاريخ النشر
2020.
عدد الصفحات
131 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة عين شمس - كلية الطب - الأمراض الباطنية
الفهرس
Only 14 pages are availabe for public view

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from 131

Abstract

Preliminary data suggest an association between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to further investigate the association between NAFLD and kidney function
Liver stiffness measurement was used to detect liver fibrosis and CAP (controlled attenuation parameter) was used to detect and quantify liver steatosis (Fibroscan®). NAFLD was defined by CAP values ≥238 dB/m.
A total of 40 subjects were enrolled in the study. Subjects are divided in two groups, group A (30) non-diabetic CKD patiens not on dialysis (19) males and (11) females, and group B (10) normal healthy subjects matched for age and sex (7) males and (3) females as a control group.
In our study, there was statistically non-significant difference between the two groups regarding age, gender and BMI.
Results of the present study revealed that the mean duration of CKD was 5.07 ± 2.43 years. Hypertension was the most common cause of CKD.
Regarding CKD stages; (56%) of the studied CKD group were at stage III, also (30%) were at stage IV and (13.3%) were at stage V.
In the present study, there was statistically significant difference between CKD group and control group regarding eGFR, s.Creatinine, BUN, microalbuminuria, albumin, Hb%, LDL, HDL, SGPT, SGOT, and HBA1C.
Results of the current study showed that total frequency of presence of steatosis whatever degree was significantly higher in CKD group than control, More than (53%) of CKD patients have steatosis of all degrees, and (30%) of conrol group have steatosis of all degrees.
Results of this study showed statistically significant positive correlation between steatosis degree and age; between steatosis degree and weight; between steatosis degree and BMI.
In our study, there was none statistically significant relation between steatosis and gender. There was statistically significant relation between steatosis and fibrosis among CKD patients
In the present study, there was statistically non-significant relation between steatosis degree and gender, statistically non-significant relation between steatosis degree and disease duration.
Results of this study showed statistically significant relation between steatosis and CKD etiology. (82.3%) of Patients with hypertension have Steatosis, (33.3%) of Patients with reflux nephropathy have steatosis, (16.7%) of Patients had other causes have steatosis, while patients had obstructive uropathy have no steatosis.
In the present study, there was statistically significant negative correlation between steatosis degree and eGFR, Hb% and HDL, and shows significant positive correlation between steatosis degree and s.Creatinine, BUN, CRP, Cholesterol, TG, LDL, SGPT, SGOT, Bilirubin, FBG and HBA1C.
Results of this study showed statistically significant positive correlation between fibrosis degree and age of CKD patients.
In our study, there was statistically non-significant relation between fibrosis degree and weight, BMI, gender, disease duration, CKD etiology, CKD stage of CKD patients.
In this study, there was statistically significant positive correlation between SGPT and fibrosis degree