الفهرس 
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Abstract
This is a case-control study conducted in cardiology department Sammanaud general Hospital from May 2017to May 2018 to investigate if intravenous heparin dosing based on LBW of obese patients would be safe and effective in achieving target aPTT within 24 hours compared to the usual practice.The study included 50 patients. Patients aged >18 years randomized into two groups. First group 1(controls) : recieved UFH based on actual body weight at an initial infusion rate of (12-16) units/kg/h .Second group2(cases): will receive UFH based on lean body weight at the same rate.Serial APTT measured every 6 hours for all patients. The study showed that In control group the count of patients who achive the target APTT(57-83 sec) within 24 hours without any complications was 15 with percentage 60 % ,While 10 patients with percentage 40 % were complicated by bleeding, while In cases group the count of patients who achive the target APTT within 24 hours without any complications was 25 with percentage 100%. Finally, using the LBW in Cases group instead of TBW in control group for calculating the therapeutic doses of UFH we achive the targeted APTT in all (100 %) patients effectively, safely, with less infusion rates,while in control group we achive the targeted APTT only in 60 % of patients with increasing risk of bleeding and being supra therapeutic range.