الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Breast cancer (BC) is the most common type of cancer among women world-wide and a leading cause of cancer related deaths. Survivin is the smallest member in the inhibitor of apoptosis (IAP) gene family. It has a potential dual role in inhibition of apoptosis by inhibiting caspase-9 and cell proliferation via regulation of mitosis. Survivin overexpression in cancer promotes survival of aneuploid cells, facilitates bypassing of cell cycle checkpoints and increases angiogenesis, thereby using its cytoprotective character to ensure tumor progression. Objectives: Investigation of immunohistochemical expression of survivin in breast carcinomas and correlation with the clinico-pathological aspects & molecular subtypes of the tumors. Materials and methods: 60 formalin fixed paraffin embedded BC tissue sections were randomly collected. Both epidemiological data and molecular subtypes were. |