الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Uric acid is the end product of purine metabolism in humans. Purines are nitrogen containing compounds, endogenous or exogenous. Uric acid passes through the liver, enters the blood stream, most of it excreted in urine. Some uric acid is degraded in the body after reaction with oxidants or peroxynitrite.
Uric acid can induce acute inflammation, activate various inflammatory transcription factors and induce systemic cytokine production and local expression of chemokines such as chemotactic protein in the kidney and cox2 in the blood vessels.
Sepsis is one of the leading causes of deaths world-wide. The patient outcome is determined by a complex interplay between the pro and anti-inflammatory responses of the body i.e., a homeostatic balance between these two competing events to be achieved for the patient‘s recovery. This was despite most deaths occurring during the immune paralysis stage of this biphasic disease.