الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Sepsis still represents a leading cause of intensive care unit (ICU) admission with a case fatality rate of 30–40%. Mannose-binding lectin (MBL) is a recognition molecule which activates the lectin pathway of the complement system. Low MBL plasma levels have been described to be associated with susceptibility to infections and poor outcome. On the other hand, the excessive activation of MBL may be responsible for an unbalanced inflammatory and coagulation response, as observed in inflammatory diseasesand transplant rejections. The aim of this work was to evaluate Validity of Mannose-Binding Lectin Serum Level in Diagnosis and Prognosis of Sepsis.
This was a prospective observational study conducted in Benha Children Hospital from April 2017 to March 2018. A total of 86 children were included as follow: 50 patients and 36 healthy children who served as a control group.
Critically ill children with an expected length of PICU stay of 48 hours or more were consecutively enrolled. Patients were sub-grouped into (1) patients with sepsis, (2) patients with non-infectious SIRS. (3) Patients without SIRS.
The diagnostic workup performed to patients included history, physical examination and investigations. The clinical and laboratory parameters were used to calculate PRISM, PIM2 and SOFA scores.
Patients were closely monitored till hospital discharge.
This study showed that:
The mortality rate was (20%). Moreover, there was no significant difference between patients with sepsis and controls regarding MBL and no significant difference between sepsis, non-infectious SIRS and non-SIRS regarding MBL level. A significant weak negative correlation was found between CRP and MBL in addition to lack of significant correlations with other clinical and laboratory variables, including the sepsis biomarkers WBC and platelet count. ROC curve analysis showed that MBL had a modest AUC while WBC had a high AUC for discriminating children with sepsis from controls. MBL was found to have a very poor performance for prediction of mortality compared with PRISM, SOFA, PIM2, hemoglobin, and ALT.