الفهرس 
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Abstract
Introduction :.Rotenone, an organic pesticide, became of significant interest to researchers compared to other neurotoxins used to establish animal models of PD as it shows the classical features of the disease..Animals and methods :.This work was carried out on thirty two adult male albino rats. They were divided into 2 groups of 16 rats each. Then, half of the rats were sacrificed by intracardiac perfusion through the left ventricle with 10% buffered neutral formalin. The midbrains and cerebella were dissected out and processed for histological and immunohistochemical staining. The midbrains and cerebella of the other half of the rats were used for neurochemical study. Paraffin sections were prepared and stained with cresyl violet and silver stains. Also, immunohistochemical staining for α-synuclein, caspase-3 and tyrosine hydroxylase were done. Homogenates of midbrains and cerebella were obtained and centrifuged to measure the levels of MDA, NO and GSH..Results :. Histological examination of the SNc of the experimental group showed reduced number and size of the nigral neurons with ill-defined nuclei. There were some shrunken hypoplastic neurons surrounded by halos. Also, there were some empty spaces indicating degenerated neurons that left empty spaces at their sites. The cerebellar cortex of the same group showed loss of the characteristic shape of most of Purkinje cells with ill-defined dendrites. Others were surrounded by empty spaces. Most of the granule cells appeared small as compared with the control group. .Conclusion:. A better understanding of the PD–related cerebellar changes would significantly contribute to the pathophysiology of PD and might help to develop new strategies and targets for treatment.