الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. Recent investigations have begun to identify genes that might be involved in AR The genes encoding cytokines and receptors in patients with AR were investigated the most . several studies have investigated single-nucleotide polymorphisms (SNPs) in genes encoding the molecules implicated in the pathogenesis of allergic rhinitis; including specific interleukins (ILs) and their receptors. Until recently it has been assumed that development and manifestation of allergic airway disease was primarily influenced by the activity of T helper (Th)1, Th2 cells and T-regulatory (Treg) cells in genetically susceptible individuals As observed in recent studies, several SNPs in the IL-23R gene are found to be associated with immune-related diseases, including Crohn’s disease, rheumatoid arthritis, Behcet’s disease, and ankylosing spondylitis This study aimed at is to investigate the association between IL-23gene polymorphisms and susceptibility to allergic rhinitis. This study included 100 patients of allergic rhinitis as case group and 75 healthy s ubject as control group collected between January 2017 and March 2017 Peripheral venous blood samples obtained under complete aseptic conditions and maximum precautions and applied into vacutainer tubes containing EDTA and stored at – 80 for molecular assay of IL 23 R genotypes.