الفهرس 
Major Depressive DisorderOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Major depressive disorder is a highly prevalent medical disorder worldwide and is considered a major contributor to disability. Poor adherence to treatment is one of the main challenges to symptom control and improve outcome.
Aim of the Work: this study was carried out to identify the relationship between medication adherence in patients with Major depressive disorder and the severity of illness.
Patients and Methods: this cohort (prospective longitudinal study) was started from January 2019 till February 2020. The subjects were selected from inpatient wards and outpatient clinics of Institute of Psychiatry, Faculty of medicine, Ain Shams University. 100 participants diagnosed with Major depressive disorder according to DSM-IV classification were enrolled in the study. Each was assessed twice 6 months apart. Arabic version of 17-item Hamilton Rating Scale for Depression was applied initially and 6 months later. Adherence was measured using the Morisky 8-Item Medication Adherence Scale.
Results: 53% showed low adherence. High adherence patients showed the highest decrease in severity while the low adherence patients showed highest severity scores.
Conclusion: Illness severity was found to be strongly associated with non-adherence to medication. Psychiatrists ought to consider factors influencing adherence to enable offering proper interventions.