الفهرس 
? Poor responders & IVFOnly 14 pages are availabe for public view
 |  | from | 138 |  |  |
| | | from | 138 | | |
Abstract
The role of progesterone supplementation as a luteal phase support in IVF cycles is well established world-wide , but the effect of luteal phase estradiol supplementation on implantation is not clearly defined.
Our study was conducted at Ain Shams University maternity hospital and a private IVF center thorough the period between April 2018 and September 2019 to find out the role of estradiol with progesterone as a luteal phase support in poor responders undergoing IVF and ICSI using gonadotropin releasing hormone antagonist protocol regarding the clinical pregnancy rate.
Out of 185 women assessed for eligibility for participation in the study, 170 women were eligible to participate, and were randomized within 24 hours of ovum pick-up to receive one of two different modes of luteal support. Nine women in both groups had their cycles cancelled and another 11 women were lost during follow up leaving only 150 women who completed the study.
There was no significant difference between both groups regarding the women’s age (mean =37.2±1.7 years) in the study group while in the control one (mean =37.1±1.9 years).
All other participants’ characteristics, the type of infertility, ovarian stimulation outcomes and hormonal levels in the early follicular phase were comparable in both groups except for the number of picked up oocytes that was significantly different between both groups; (mean= 2.4, SD = 0.8) in the study group while in the control one (mean = 2.1 , SD = 0.8) , p value =0.041.
Pregnancy outcomes showed significant difference between both groups with 42.4% in the study group achieved chemical pregnancy versus 17.6% in the control group with a p-value<0.001. Regarding the clinical pregnancy rate, it was 36.5% in the study group vs. 15.3% in the control group with a p-value= 0.002, and the live birth rate was 30.6% vs. 11.8% with a p-value=0.003 in both study and control groups respectively.