الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
HCV infection is a major global health problem with more than 170 million people infected with the virus worldwide. HCV is one of the main health problems in Egypt, where the overall HCV antibody prevalence is 14.7% among the adult Egyptians. The outcome from acute HCV infection (resolving or chronicity) is generally believed to be determined by the competence of host innate and adaptive immune responses.
HCC accounts for 6% of all cancers worldwide. It is the fifth most common malignancy, with an estimated half million new cases diagnosed per year globally, and mortality rate equivalent to its incidence. In this study, we aimed to find the possible association between the host genetic factor (IL6-rs1474347 and IL10-rs1800896 SNP) and the outcome of HCV infection among Egyptian patients infected with HCV genotype 4 (HCV-4).
For this purpose, genotyping of the two SNP was done by Real Time- PCR and showed significant difference among patients with HCV chronic infections, cirrhosis and those with HCC in terms of age, sex, platelet count, AST, total bilirubin, presence of mild or moderate ascites, AFP level, splenomegaly and the incidence of mortality rate. This study showed significant difference between IL-6rs1474347 A/A SNP HCV out comes. As it was found that patients with IL-6rs1474347 A/A SNP had more chances to develop chronic HCV infection, cirrhosis and more chances to develop HCC. In addition, we found that low frequency of IL-6rs1474347 A/C increase the risk of developing chronic HCV infection and the progression of cases to cirrhosis and HCC in comparison to control group.
Furthermore, high frequency of IL-10rs180096 T/T genotype was observed among patients with HCC. As HCV patients with IL-10rs180096 T/T SNP had more chances to develop HCC. Inddition, low frequency of IL-10rs180096 T/C SNP among HCV patients compared to control, was found to affect HCV infection outcome and increase the risk to develop liver cirrhosis and HCC.
In conclusion, IL-10 and IL-6 cytokines play important roles in the infection processes, inflammation and cancer development. The presence of IL-6 rs 1474347 A/A genotype and the absence of A/C genotype among HCV Egyptian people make the patients at risk for the progression of the infection. In addition, the presence of IL-10 rs180096 T/T genotype and the absence of T/C genotype increase the susceptibility to develop HCC. So, screening for IL-6 rs 1474347 A/A genotype and IL-10 rs180096 T/T genotype as well as the determination of AFP level are considered good markers for the susceptibility of patients to develop HCC.