الفهرس 
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Abstract
The present study aimed to investigate the in vitro antioxidant, antimicrobial and antitumor activities of P. armeniaca L. and Z. Jujuba seed extracts, their active components and mixtures of them, additionally studying their therapeutic effects on chemically induced hepatocarcinogenesis mice model to highlight their related molecular mechanisms. In this study, the antioxidant activity (ABTS and DPPH) were measured for all extracts and their active compounds included in this study, while the antimicrobial and antitumor activities were applied only to the most active one. it can be concluded from the current results that different drugs, and their combinations inhibited hepatocarcinogenesis induced by DMBA to a great extent via induction of apoptosis through modulation of the expression of caspases-3 and Bcl-2, induction of autophagy through modulation of Beclin-1 and prevented inflammation and cancer cells proliferation by the inhibition of NF-κB, COX-2 and TNF-α induced by DMBA. Therefore, these different treatments may be a promising chemotherapeutic agent for liver carcinogenesis. Further, the more potent ameliorative effect of selected different combinations may provide evidence for the synergistic action of these different combinations. It is also promising that such valuable agents can serve as an adjuvant to enhance the efficacy of other known chemotherapeutics regimens.