الفهرس 
Metabolic syndromeOnly 14 pages are availabe for public view
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Abstract
Metabolic syndrome is an accumulation of several disorders, which together raise the risk of developing atherosclerotic cardiovascular disease, insulin resistance, diabetes mellitus and vascular and neurological complications such as a cerebrovascular accident.Metabolic disarrangement becomes a syndrome if the patient has any three of the following: Waist circumference more than 90 cm in men and 80 cm in women.Elevated triglycerides 150 mg/dL or greater.Reduced high-density lipoprotein cholesterol (HDLc) less than 40 mg/dLin men or less than 50 mg/dL in women.Elevated fasting glucose of l00 mg/dL or greater.Blood pressure values of systolic 130 mmHg or higher and/or diastolic85 mmHg or higher.
11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene (located atchromosome lq32-41) encodes 292 amino acid protein, 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) enzyme.
11β-HSD1 enzyme is mostly expressed in the liver, adipose tissue, bone, lung and the central nervous system. It normally converts the inactive hormone cortisone into its active form cortisol acting as a reductase. 11β-HSD1 enzyme is bidirectional, able to act as both a reductase (activating glucocorticoids) and a dehydrogenase (oxidase, inactivating glucocorticoids). However, its main function is as a reductase in intact cells such as hepatocytes, adipocytes and myocytes, supported by a higher affinity for cortisone than cortisol.
Recent studies strongly suggests that there is a pathogenic role of glucocorticoids and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in obesity and the metabolic syndrome.
The aim of this study is to study the role of 11beta-hydroxysteroid dehydrogenase Type 1 gene rs12086634 and rs846910 single nucleotide polymorphisms and serum cortisol level in metabolic syndrome patients and show its association with gender and other parameters of metabolic syndrome.
The present study was conducted on seventy subjects: 35 metabolic syndrome patients selected from Internal Medicine Department, Menoufia University Hospital and 35 apparently healthy subjects served as controls.