الفهرس 
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Abstract
Alopecia areata (AA) is an autoimmune disease of the hair follicle, resulting in acute or chronic patches of hair loss, total hair loss of the scalp (alopecia totalis, AT), or complete hair loss of entire body and scalp (alopecia universalis, AU). It is a disease with significant impact on health‐related quality of life, in particular to the domains of role emotional, mental health and vitality. It affects all age groups and different ethnicities, with an equal sex distribution. At any given time, 0.2% of the population has AA, and approximately 1.7% of the population will experience an episodes of AA during their lifetime One-third of patients will experience spontaneous remissions within the first year. However, many patients‘ disease will progress to alopecia totalis or alopecia universalis. Persistent moderate-to-severe. The exact etiology is unknown, and research is focusing on genetic factors, autoimmune factors, drugs, trauma, infections, psychological factors and oxidative stress. The disequilibrium between oxygen reactive species and antioxidants leads to oxidative damage in cellular molecules. Since lipids are more sensitive to the harmful effects of free radicals several authors aimed, and succeeded, to prove that lipid peroxidation products are higher in patients with alopecia areata than in healthy controls while the antioxidant activity which plays a very important role in protection against oxidative stress, is defective
Human serum paraoxonase- 1(PON-1) is an esterase enzyme, exclusively located on HDL in the serum. Its main function is to hydrolyze organophosphate substrates and metabolizes lipid peroxides leading to protection against accumulation of LDL.
Paraoxonase (PON) has gained popularity to demonstrate antioxidant properties. Plasma paraoxonase 1 (PON1) has been shown to reduce oxidative stress and protects low- and high-density lipoprotein against oxidation PON1 has lipophilic antioxidant power; it is one of the endogenous free-radical-scavenging systems in the human body.
The aim of this work was to assess serum level of PON 1 and lipid profile in AA patients in a trial to clarify its possible role in the pathogenesis of AA and to correlate its level with disease severity.
It was conducted on two groups: group 1: included 25 Alopecia areata patients & group 2: included 25 healthy controls with age and gender matched. Every studied subject was subjected to detailed history taking, general clinical examination, local dermatological examination &measurement of serum PON 1 and lipid profile. 5ml Blood were collected from every subject under complete aseptic condition using sterile vacuationers, left to stand at room temperature, then centrifuged at speed of 2000 – 3000 r.p.m for 20minutes. The serum obtained was stored at -20 c until analysis of PON 1 and lipid profile.