الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a chronic, immune-mediated, inflammatory disease of the skin. It is a multifactorial disease with genetic background, environmental triggering factors, immunological mediators.
Most epidemiologic studies suggested that patients with psoriasis are at increased risk of cardiovascular disease and metabolic syndrome.
The aim of this study was to evaluate the serum level of ghrelin, obestatin and ghrelin obestatin ratio and investigate whether body adibosity affect their levels in both psoriatic patients and controls.
Ghrelin is a unique 28 amino acid peptide; it has been studied in psoriatic patients.
Obestatin is a 23 amino acid peptide which is derived from the same 117-residue prepropeptide as ghrelin and this is the first study measuring its level in psoriatic patients.
The current study was carried out on 40 psoriatic patients (group A) and 40 age and sex matched healthy controls (group B), admitted to dermatology clinic Alexandria Main University Hospital.
All patients with chronic generalized plaque psoriasis met the inclusion criteria.
All patients were subjected to history taking including the age, sex, duration of the disease, family history of psoriasis and previous treatment.
General examination of both patients and controls including BMI, waist circumference, Waist hip ratio and body composition (lean mass, fat mass and percent body fat) was done.
Local examination to asses severity of psoriasis by using PASI score was done.
The study population was divided into 2 groups according to BMI (Normal and non-normal weight) for evaluation of the effect of body adiposity on the level of both ghrelin and obestatin.
This study found that there were no statistically significant differences between groups regarding ghrelin, obestatin and ghrelin obestatin ratio but there was a significant positive correlation between ghrelin and PASI score.
No statistically significant differences regarding ghrelin, obestatin and ghrelin obestatin ratio were noted among groups of normal versus non-normal weight subjects.
Collectively, this study suggests that these metabolic peptides are not strong independent biomarkers that may play a role in evaluating the severity of psoriasis or the associated metabolic perturbations. At least in patients with mild psoriasis without arthritic involvement, who constituted the majority of the patient population in the present study, careful clinical evaluation remains the gold standard for assessing the presence and progress of the disease