الفهرس 
C OW M ILK P ROTEIN A LLERGYOnly 14 pages are availabe for public view
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Abstract
Secretory IgA is the principal immunoglobulin on mucosal surface of humans and mammals. Displaying a very different molecular form from the IgA present in the circulation. Operating in a mechanism separating the inside of the body which needs to remain sterile from the outside world rich in antigenic stimuli. Through Immune exclusion and the excretory function of secretory IgA, it blocks microorganisms and toxins from attaching to mucosal target epithelial cells in the GIT, delaying their intrinsic potential to adhere to or penetrate the epithelium.
Our study was a randomized case control study that was carried out on 90 children in the pediatric hospital Ain Shams University. Cases enrolled in our study were children of age group from 1 month up to 3 years old who were already diagnosed with food allergy following in the GIT clinic. While Controls are age matched siblings of patients presenting to the outpatient clinic.
This study shows that patients diagnosed as CMPA complained of frequent GIT symptomsWith 91% of patients had diarrhea, 71% complained of vomiting, 6.7% suffered from constipation while 15% complained of melena, Failure to weight gain 29%.
This study reveals a positive correlation between secretory IgA deficiency and recurrent hospital admissions duo to recurrent gastroenteritis and chest infection showing that the frequency of recurrent chest Infections and hospital admissions were much higher in the secretory IgA deficient group in comparison to the non-deficient group while the figures of recurrent GE was even higher among those with SIgA deficiency.
In conclusion Secretory IgA deficiency was more frequent among CMPA patient suggesting it has a role in the development of food allergy which should be studied further. Also secretory IgA deficient patients develop more episodes of gastroenteritis and chest infections in comparison to the non-deficient group.