الفهرس 
Breast CancerOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Breast Cancer (BC) is by far the world’s most common cancer among women, and the most cause of women cancer related death. In Egypt, breast cancer is estimated to be the most common female cancer, the incidence rate is 48.8/105. Over the last 30-40 years, substantial progress has been made in the diagnosis and treatment of breast cancer. An effort has been made to detect risk factors and genetic factors that contribute to the risk of breast cancer development. Breast cancer oncogenesis implies complex interactions between genes and epigen¬etic alterations. Genetic polymorphism studies are useful for identifying susceptibility genes as well as predictive biomarkers.
Aim of the Work: The aim of the present study is to investigate the association between MDR1gene C3435T polymorphism and breast cancer risk as well as the clinicopathological features of the disease and the tumor marker CA15.3.
Patient and Methods: The study was conducted on 40 BC patients in addition to 40 age matched subjects serving as a healthy control group. Determination of MDR1 gene polymorphism C3435T was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results: The result of the present study revealed that there was high significant difference in frequency of the (C/C, T/C and T/T genotypes) in the breast cancer patients group compared with control group with high significant difference was detected in frequency of the C allele and T allele in the breast cancer patients group compared with control group. Also studied MDR1 genotypes and alleles had shown non significant difference in distribution related to clinico-pathological parameters nor CA15.3.
Conclusion: the results of the present study demonstrated that breast cancer patients differ from healthy subjects for MDR1 C3435T gene polymorphism. According to our data, we can say that T allele carriers are at high risk for development of breast cancer. On the other hand, in breast cancer patients, clinical parameters and other tumor markers for breast cancer as (CA15.3) were not different among CC, CT and TT genotypes, as well as T and C allele carriers. The results may be providing a framework for further analysis of the importance of Pgp in interindividual variability of breast cancer risk.