الفهرس 
المقدمةOnly 14 pages are availabe for public view
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Abstract
This thesis represents a study of the interaction between tris(hydroxymethyl)aminomethane, THAM and 2,5-dichloro-3,6-dihydroxy-1,4benzoquinone (chloranilic acid, CLA), part 1, as a primary step, followed by studying the product coordination behavior toward different copper(II) salts and find out whether the anion affects the product structure or not, part 2.
However, two isolated solids are obtained from the reaction of CLA and THAM in mole ratios 1:1 and 1:2.Their formation and structures were confirmed via elemental analysis, FTIR, 1HNMR and single-crystal X-ray crystallography. According to X-ray crystallography, the 1:1 product form an asymmetric molecular structure having inter and intra molecular hydrogen bonding, whereas the 1CLA:2THAM product formed molecular ionic structure through proton transfer and hydrogen bonding. In solution the behavior is different as they give only 1:1 CT- complex as seen from the UV-Vis spectral study and job`s method in solvents methanol, ethanol and acetonitrile. Furthermore, the calculations from applying the density functional theory (DFT) and time dependent density functional theory (TD-DFT) showed good agreement with slight differences in the bond lengths and angles. Since the CT-complexes performed as 1:1 in solutions, the product, named as CT-complex II, is selected to study its coordination behavior towards CuCl2.2H2O , Cu(NO3)2.3H2O and Cu(CH3COO)2.H2O in mole ratios (1:1) and (1:2), in ethanolic solutions and as a result different Cu(II) complexes have been isolated. The products are characterized via elemental analysis, FTIR, UV-Vis., electron paramagnetic resonance spectroscopy (EPR) and magnetic susceptibility studies. The magnetic moment calculations suggest the octahedral geometries for [Cu2(CLA)(THAM)2(H2O)4],a ,[Cu2(CLA)(THAM)2(H2O)4].H2O,c, [Cu2(CLA)(THAM)2(CH3COO)2(H2O)2],e, [Cu(CLA)(THAM) (CH3COO) (H2O)],f, whereas, [Cu2(CLA)2(THAM)2(NO3)2], b and [Cu2(CLA)2(THAM)2Cl2], d, are of tetrahedral geometry. The CT-complex, II and the derived complexes have been evaluated as antimicrobial and antifungal reagents, in addition to their in vitro cytotoxic activity against the mammalian cell line, breast carcinoma cell line (MCF7) showing promising results.