الفهرس 
صفحة العنوانOnly 14 pages are availabe for public view
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Abstract
Liver cancer is the sixth most commonly diagnosed cancer and the
fourth leading cause of cancer death worldwide. Nowadays, natural
products represents a good source of anticancer drugs. In this study,
six sediment samples were collected from lsmailiyah canal in Cairo,
and one sediment was collected from Ras Mohamed, Sharks Bay,
South of Sini, Egypt. The collected samples were used for the
isolation of pigmented actinomycetes. Seventeen actinomycetes were
isolated and recognized by morphological and microscopic
examinations. The actinomycete EGYl was found to produce two red
compounds that were identified as Sharkquinone (1) and SS-228R
(2). One of the isolated strains, actinomycete ABS, was found to
produce an interesting yellow pigment in a good yield. The structure
of the major compound was characterized by spectroscopic methods,
including NMR and mass spectrometry data, and identified as
Heliomycin (3). The influence of cultural parameters affecting the
production of the biomass including different culture media, pH
values, temperatures and incubation periods were investigated.
Maximum production of secondary metabolites (2.78 g/I) was found
in the culture medium of Waksman at initial pH 7.5 for four days at
35°C. The antimicrobial activity of Heliomycin (3) was evaluated
against Gram-positive bacteria, Gram-negative bacteria and fungi.