الفهرس 
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Abstract
Glanzmann’s thrombasthenia is an autosomal recessive rare bleeding disorder, where bleeding time is prolonged, platelets count is normal. Although thrombasthenia is a rare disorder, it has been found with increasing frequency in some regions of the world where consanguinity is common. The aim of the present study is to: - Evaluate glycoproteins IIb-IIIa levels (CD41and CD61) by flowcytometry on the platelet surface of patients with GT for proper typing. - Application of a bleeding questionnaire to assess bleeding symptoms and severity. - Correlation between scores of bleeding questionnaire and different types of GT. All patients were subjected to the following:- History taking, physical examination, clinical investigations and specific laboratory investigation by Flowcytometry technique. Results:- Regression analysis showed that double expression levels of CD41, CD61 and CD41 are good predictions of GT. Flow cytometry was found to be the more sensitive technique (75%) to evaluate GT patients. These findings were applied to our results as Receiver Operating curve and the associated (AUC) for CD41, CD61 and double expression% showed that CD41% and double expression% are the best discriminator of GT from healthy controls with cut off value of 57.8 and 57.75% respectively Conclusion :- from our study, we can conclude that type I GT is the most common type in our patients with lowered mean CD41 expression in comparison with CD61. Also CD41 and double expressing platelets could discriminate GT patients from healthy controls with cutoff value of 57%. Recommendations:- Since flow cytometry is now being increasingly used to confirm the presence or absence of platelet GPs, we recommend to be performed early in in the screening and typing of GT patients for accurate diagnosis and before platelet transfusion to avoid any diagnostic dilemmas.