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العنوان
Synthesis and Reactions of Pyrimidine Derivatives =
المؤلف
Ali, Fatma Elzaharaa Mahmoud Elsaid.
هيئة الاعداد
مشرف / Prof. Dr. Mahmoud Ahmed Nassr
مشرف / Prof. Dr. Mohamed Gaber Marei
مشرف / Prof. Dr. Kamal Fahmy Mohamed Atta
مشرف / Assoc. Prof. Dr. Omaima Osman Mahmoud Farahat
الموضوع
Pyrimidine Derivatives.
تاريخ النشر
2020.
عدد الصفحات
172 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء
تاريخ الإجازة
10/10/2020
مكان الإجازة
جامعة الاسكندريه - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

from 190

from 190

Abstract

The first chapter is the introduction which comprises a reviews of the chemistry of Triazolopyrimidine derivatives. The most important methods of synthesis of these compounds as well as their reactions and biological activities are considered.
The second chapter is devoted to a discussion which divided into two main parts: First part started with synthesis of the starting material 2-hydrazinyl-4,6-diphenylpyrimidine (102) which can be synthesized via nucleophilic substitution reaction of 4,6-diphenylpyrimidine-2-thiol (101) with hydrazine hydrate. Furthermore, 4,6-diphenylpyrimidine-2-thiol underwent nucleophilic substitution reactions with bromine in acetic acid, iodine monochloride in acetic acid and nitric acid in acetic acid to give 5-bromo-4,6–diphenylpyrimidine-2(1H)-thione (103), 5-iodo-4,6–diphenylpyrimidine-2(1H)-thione (104) and 5-nitro-4,6–diphenylpyrimidine-2(1H)-thione (105), respectively.