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Abstract The first chapter is the introduction which comprises a reviews of the chemistry of Triazolopyrimidine derivatives. The most important methods of synthesis of these compounds as well as their reactions and biological activities are considered. The second chapter is devoted to a discussion which divided into two main parts: First part started with synthesis of the starting material 2-hydrazinyl-4,6-diphenylpyrimidine (102) which can be synthesized via nucleophilic substitution reaction of 4,6-diphenylpyrimidine-2-thiol (101) with hydrazine hydrate. Furthermore, 4,6-diphenylpyrimidine-2-thiol underwent nucleophilic substitution reactions with bromine in acetic acid, iodine monochloride in acetic acid and nitric acid in acetic acid to give 5-bromo-4,6–diphenylpyrimidine-2(1H)-thione (103), 5-iodo-4,6–diphenylpyrimidine-2(1H)-thione (104) and 5-nitro-4,6–diphenylpyrimidine-2(1H)-thione (105), respectively. |